Information about:

Beckwith-Wiedemann syndrome

What is Beckwith-Wiedemann Syndrome?

Beckwith-Wiedemann Syndrome (BWS) is a congenital overgrowth syndrome, which can affect all systems of the body. It was first recognised in 1963-64 by Dr J. Bruce Beckwith, a paediatric pathologist in America and, independently, by Dr H.E. Wiedemann, a German geneticist. Each had found a similar set of congenital abnormalities in children, which could not be found in any other disorders – in other words, a new syndrome.

BWS occurs once in approximately every 15,000 births. This figure may be an under-estimate as mild cases may not being be diagnosed. In most cases it appears to be an isolated event with no known family history, but the condition can be inherited in about 15%.

Like many such disorders, Beckwith-Wiedemann Syndrome can vary in its effects from child to child: some children are relatively mildly affected while others have a wider range of physical problems. There are, however, some characteristics that are common to most BWS children. Most problems can be helped or even solved provided that accurate diagnosis is made and appropriate treatment started. Those children who survive infancy, the great majority, are usually healthy with their growth and appearance gradually becoming normal.

What are the main characteristics of BWS?

Diagnosis of BWS

What is the treatment?

What causes BWS?

EMQN BWS Summary Report